Hormone Foundation was developed to target the foundational systems that influence hormone balance, including estrogen metabolism, liver detoxification, gut health, and oxidative stress. The interconnected functions of the liver, gut, and cellular antioxidant defenses play a vital role in how hormones are processed, transformed, and eliminated. Addressing these pathways is essential not only for managing hormonal shifts, but also for supporting the body’s resilience and long-term hormonal equilibrium.

This comprehensive, systems-based approach is what makes Hormone Foundation unique: It supports the body’s natural ability to process hormones efficiently, neutralize reactive metabolites, and maintain healthy estrogen balance through targeted detoxification and defense mechanisms—without overwhelming or overstimulating a single pathway. It does this by utilizing key bioactives including the Complete Turmeric Matrix, hops strobile extract, black kale extract, Quatrefolic^® folate, epigallocatechin gallate (EGCg), and tributyrin (CoreBiome^®).

Suggested Use:

1 capsule per day or as recommended by your health care professional.

Complete Turmeric Matrix (CTM)

The CTM provides a full spectrum of curcuminoids and essential oils that support the body’s natural detoxification processes, including the normal metabolism of estrogens through the activity of Phase I and Phase II enzymes.

Hops Strobile Extract

Hops strobile extract supports the body’s natural estrogen metabolism pathways by supporting Phase I detoxification and helping maintain aromatase (CYP19A1) activity within a normal range.

Black Kale Extract (18% Glucoraphanin)

Black kale extract is a rich source of glucoraphanin, a naturally occurring, sulfur-containing compound that supports the body’s normal detoxification pathways. Glucoraphanin is a precursor to sulforaphane, which has been shown to promote Phase II detoxification enzyme activity, assisting in the efficient processing and elimination of endogenous and environmental compounds.

Folate (as Quatrefolic^® 5-MTHF)

Folate (as Quatrefolic^®) is essential for methylation, a key biochemical process involved in estrogen metabolism. It facilitates the conversion of catechol estrogens, such as 2-hydroxyestrone and 4-hydroxyestrone, into methylated derivatives for safer elimination, thereby promoting hormonal balance and reducing oxidative stress.

Epigallocatechin Gallate (EGCg)

EGCg, a green tea polyphenol, enhances antioxidant activity, which helps maintain cellular integrity during the natural processing of estrogen. EGCg can also influence estrogen receptor (ER)-dependent expression of estrogen target genes and ER-independent signaling pathways.

Tributyrin (CoreBiome^®)

Tributyrin is a precursor to butyrate, a short-chain fatty acid that supports a healthy digestive environment and plays a key role in estrogen metabolism.